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Besides their special organization in lipid domains (lipid rafts) of the membrane lipid bilayers, some sphingolipids, e.g., ceramides, sphingosine, and sphingosine-1-phosphate have been described to function as lipid-derived second messengers mainly regulating fundamental cellular pathways such as apoptosis and differentiation [119, 120]

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L-carnitine co-incubation fully rescued colistin-induced damage in isolated mitochondria as well as in primary cultured tubular cells, whereas the protection in vivo was only partial

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